The patient, male, was admitted to the hospital with yellow urine for more than 20 days and scleral yellowing for 7 days. On examination: yellow scleral staining of skin, flat abdomen, no varices, no gastrointestinal pattern and peristaltic waves, soft abdomen, no pressure pain and rebound pain, liver and spleen not palpable under the ribs, negative Murphy’s sign, no percussion pain in the liver and kidney area, negative mobile turbid sounds, and acceptable bowel sounds. Combining history, signs, ultrasound, CT and CA-199, the preoperative diagnosis was considered obstructive jaundice and bile duct cancer in the porta hepatis, and the patient had significantly elevated bilirubin. After discussion and active preoperative preparation in F5C ward of general surgery, this patient was decided to undergo laparoscopic radical resection of hilar cholangiocarcinoma with five-hole method to place the operating instruments. The hepatoduodenal ligament was edematous, and multiple enlarged lymph nodes were seen inside, the large one was about 1.2*1 cm. The hepatoduodenal ligament was dissected with ultrasonic knife, and the right gastric artery, left hepatic artery, right hepatic artery, intrinsic hepatic artery, common hepatic artery, and gastroduodenal artery were dissected in order, and the common bile duct was cut at the upper edge of duodenum, and “skeletonized “skeletal” clearance of the hepatoduodenal ligament, then freeing the gallbladder, resecting the tumor and gallbladder together, breaking the jejunum about 20 cm from the flexural ligament, performing end-lateral anastomosis between the common bile duct and distal jejunum, then performing end-lateral anastomosis between the small intestine, the operation went smoothly, the operation time was more than 5 hours, postoperative pathology showed: (common bile duct) high-moderately differentiated adenocarcinoma, the gallbladder and surrounding fatty tissue were found to be multifocal high After surgery, the patient was discharged from the hospital after the drainage tube was removed and the stitches were removed. Radical hepatoportal cholangiocarcinoma is a major surgery in hepatobiliary surgery, and laparoscopic hepatoportal cholangiocarcinoma radical surgery is a more difficult surgery, which requires laparoscopic “skeletonization” of the hepatoduodenal ligament, biliary-intestinal anastomosis and intestinal-enteric anastomosis, requiring not only proficiency in open surgery, but also excellent laparoscopic skills. The laparoscopic skills of the surgeon are relatively few in China, and there is no such report in Shandong Province after searching. Our general surgery department has rich experience in hepatobiliary surgery and rich reserve of laparoscopic techniques, and successfully performed the first laparoscopic radical surgery of hepatoportal bile duct cancer in Shandong Province, which has gained valuable experience for the further development of laparoscopic biliary surgery in our hospital. At the same time, laparoscopic surgery is less traumatic, with faster recovery, less pain, fewer complications and shorter hospital stay, which is more easily accepted by patients.