HPV high-risk 33-positive patients with good body resistance can usually turn negative in about six months to a year, but this should not be generalized. HPV33 high-risk positive can lead to cervical cancer or precancerous lesions, clinical attention should be paid. However, HPV infected patients have a certain degree of self-healing, and those with strong body resistance can turn negative on their own without medication. If some patients cannot recover from HPV, they need to use interferon gel or povidone suppositories vaginally under doctor’s guidance, usually for three or six months, and repeat the HPV test after three courses of treatment; however, if the patient has not converted to HPV after half a year of treatment, it is a persistent infection, and the patient needs to repeat the TCT test regularly for the early detection of epithelial lesions of the uterine cervix and timely treatment. In addition, patients should also pay attention to vulvar hygiene during treatment, try to wear loose cotton underwear, and use boiling water to sterilize. At the same time, avoid eating spicy and stimulating food, pay attention to regular work and rest, do not stay up late, and can be appropriate outdoor exercise to improve the body’s resistance.