Syphilis is caused by syphilis spirochete infection, mainly through sexual contact transmission, vertical transmission, that is, mother-to-child transmission, and blood transmission, the three most important ways of transmission, but also through drug use or some other ways of transmission is relatively rare. The treatment of penicillin is preferred in the early stage, such as benzathine penicillin once a week, a total of three weeks of treatment can be. After treatment, the titer should be rechecked once every three months, if the titer is reduced by more than four times, it means it is effective and can continue to be observed. The titer should be checked once every three months in the first year, once every six months in the second year, and once at the end of the third year. After one year, if the treatment is effective, the infectiousness is gradually reduced, and after two years, there is basically no infectiousness. Therefore, it is necessary to observe and avoid sexual life at the same time when actively treating Mui.