There are no exact statistics on whether and how long it takes for paralysis to occur in patients with ankylosing spondylitis, and it is based on a combination of factors such as the characteristics of the patient’s condition, the effectiveness of treatment, and the patient’s general physical condition. In patients with ankylosing spondylitis who have only spinal joint lesions, ankylosing deformities of the spine may occur in the later stages of the disease, but they can generally walk on their own and are less likely to become paralyzed in bed and unable to move. However, there are patients with hip and peripheral joint lesions in addition to spinal joint lesions, especially hip lesions that can affect standing and walking activities, and even paralysis in bed. Currently, there are more ankylosing spondylitis treatment drugs, the effect is obvious, and patients who receive systematic treatment are generally able to control the disease at a stable level, less joint ankylosis deformity. Therefore, patients with ankylosing spondylitis should receive systematic and standardized treatment as early as possible, along with appropriate exercise to prevent muscle atrophy and adhesions.