When gallbladder stone symptoms strike, patients often come in quickly for treatment because they cannot tolerate the severe pain. However, often those painless gallbladder stones that have lived peacefully and quietly with the patient for a long time are easily overlooked. These patients are known to have stones in their gallbladder through physical examination, but have no pain, nausea, vomiting or other uncomfortable symptoms, and are medically known as “painless gallbladder stones” or “resting gallbladder stones”. Some of these patients (30%) do not develop stones for life, but most of them will develop symptoms sooner or later. It can strike while you are sleeping, while you are working, or while you are traveling. It is like a “time bomb” in your body. ”Painless gallbladder stones may become lodged in the gallbladder, causing fluid accumulation and acute inflammation of the gallbladder, which may require emergency treatment. If small stones are discharged into the common bile duct, the formation of secondary bile duct stones may cause biliary obstruction and symptoms of acute cholangitis such as skin yellowing, high fever, severe abdominal pain, etc. Acute cholangitis without timely surgery to relieve obstruction will lead to serious infection and life threatening shock. In addition, stones discharged into the common bile duct can also cause obstruction of the pancreatic duct and cause pancreatitis, of which the severe type is very dangerous, with a mortality rate of about 20%. Especially, patients with combined diabetes and cardiopulmonary diseases should pay more attention because the acute attack of gallbladder stones can aggravate these comorbidities. Therefore, the sooner these patients have surgery, the better it is for their recovery. If there is a delay and their health quality decreases, surgery at this time will increase the risk instead. Gallstones are an important causative factor of gallbladder cancer. As gallbladder stones cause chronic inflammation of gallbladder, after long-term stimulation of gallbladder by stones, “painless gallbladder stones” may also become cancerous. Due to the invasion of surrounding organs by tumor, radical surgery cannot be performed, and only palliative treatment can be adopted. The average survival is only about half a year, and the prognosis is very poor. Similar situation happens in clinical practice, and patients and their families often regret. Reminder: “painless gallbladder stones” patients should seek medical attention at the right time, the doctor will develop a targeted treatment plan after careful analysis, and choose a good time for surgery. The development of minimally invasive laparoscopic surgery has provided a treatment method for gallstones with minimal trauma and rapid recovery.