The symptoms of headache should first be clarified and the cause should be dealt with by targeted medication. Some people may suffer from headache due to chronic lack of sleep caused by excessive work pressure, which can easily cause mental tension, so they should pay attention to rest and restore the normal physiological function of the brain, and can be treated with appropriate nerve-nourishing drugs such as vitamin B12, methylcobalamin tablets and glutamate. Patients with long-term hypertension may experience a sharp rise in blood pressure due to external stimuli, which may cause headache. In case of vascular neuropathic headache, treatment with ibuprofen extended-release capsule, diclofenac sodium, acetaminophen and other drugs can achieve rapid relief of headache, and in addition, attention should be paid to vitamin supplementation, good habits of life and rest, and avoid emotional stimulation in daily life.