There is no definitive answer to how long a syphilis spirochete antibody-positive patient can survive. It is related to the type of antibody, the severity of the disease, the progress of the disease, the treatment, and the individual’s constitution. Syphilis spirochete antibodies are divided into non-specific and specific antibodies. If only the non-specific antibodies are positive, it is not necessarily syphilis infection, but may be systemic lupus erythematosus, etc., which is not very life-threatening after active treatment. If the specific antibody is positive, or both, the patient is infected with syphilis, and after early and active treatment, the patient can be cured, so there is no question of how long the patient will live. If the patient is not treated or treated improperly and the disease progresses faster, late cardiovascular syphilis or late neurosyphilis may appear 3-20 years after infection, which can be life-threatening in severe cases. In conclusion, if syphilis has been diagnosed, it is recommended that early standardized treatment according to the course of treatment can mostly be cured. However, in order to understand the treatment situation and avoid recurrence or reinfection, patients need to insist on review for at least 3 years, once every 3 months in the first year, once every 6 months in the second year, and once at the end of the year in the third year.