On the issue of positive syphilis-specific antibodies and negative non-specific antibody RPR test, first of all, we should repeat the check once using several different tests, for example, our section will use three different methods to repeat the detection of syphilis-specific antibodies to rule out false positives, if indeed TPPA and other specific antibodies test positive, non-specific RPR negative results are reliable, analyzed as follows: First: the vast majority of cases This means that the patient has been infected before, has been cured or self-healing, now there is no infectiousness can not need treatment, first observe after six months and then recheck, some people are in this state for life; Second: the rare case is the infection of syphilis very early, RPR can not be measured, TPPA produced a little earlier time, this situation will find the problem once again; Third: the very rare case is the patient has an immune Defective, infected with syphilis but antibody production problems, all syphilis patients must do tests to exclude HIV infection, but also to exclude some other congenital and acquired diseases that have an impact on antibody production; Fourth: Very rare late syphilis serology may be negative. Fifth: because all the tests can not be 100% guaranteed that there is no error, extremely isolated cases are indeed not syphilis, really false positive, you can check the fluorescent dense spirochete antibody adsorption test (FTA-ABS) test, this test false positive rate is very low. Some people are really not sure they can play benzathine penicillin three times.