Syphilis stage III is advanced syphilis, which causes tissue and organ destruction, and the survival time of patients varies from person to person. Syphilis is caused by syphilis spirochete infection, which is a sexually transmitted disease and is mainly transmitted through sexual contact, mother-to-child and blood. The disease can be divided into three stages according to the clinical manifestations. Stage III syphilis is advanced syphilis, with an infection time of more than 2 years, which causes tissue and organ destruction, but syphilis responds very well to treatment, and even advanced syphilis can be cured after regular treatment, and if there are no other complications and sequelae, it has almost no effect on life expectancy. If patients with stage III syphilis cause substantial damage to vital organs, the consequences are more serious, such as cardiovascular syphilis, which may endanger the patient’s life at any time. Therefore, syphilis patients should undergo early standardized treatment, avoid intercourse during treatment, sexual partners need to be treated at the same time, disinfect clothing and household items, keep the pubic area clean, eat a light diet, and avoid stimulating food.