Cephalosporins can indeed be used to treat syphilis, but this is not the drug of choice in the treatment of syphilis. The preferred drug in syphilis treatment is long-acting penicillin, which is commonly used clinically as benzathine penicillin, which is injected intramuscularly once a week, and three times is a course of treatment. Only when the penicillin allergy can be considered to replace other drugs, such as ceftriaxone, but because ceftriaxone generally use intravenous injection for treatment, clinical many patients regularly come to the hospital injection is not very convenient, so you can also choose tetracycline and macrolide drugs for replacement, such as doxycycline, erythromycin, and azithromycin, these drugs can also be.