Hepatitis B 245 positive item 4 usually does not disappear. As it mostly presents positive after the hepatitis B virus has infected the body, it indicates that the virus is replicating, but is not particularly active and is a sign of a good prognosis. Hepatitis B 245 positive refers to the results of the five hepatitis B items, namely positive hepatitis B surface antibody, hepatitis B e antibody and core antibody. The fourth item, hepatitis B e antibody, is a mark left by the hepatitis B virus only after it infects the body. A positive hepatitis B e antibody indicates that the patient is less infectious and that viral replication is reduced or in remission, which is a sign of a good prognosis. However, there are some patients who are positive for hepatitis B e antibody, but their illness is prolonged, mostly due to the infection of mutated hepatitis B virus, in which case, although item 4 is positive, the virus is still replicating and the illness can be aggravated. Therefore, a positive result of hepatitis B 245 during the hepatitis B half test often represents that the body has been infected with hepatitis B virus in the past and the virus has been in remission. At this point, liver function tests are feasible, and if there is no viral replication, no special treatment is clinically necessary.