With the integration of western lifestyle and the increasing aging of the population, the prevalence of prostate cancer in China is increasing geometrically. Due to the special nature of prostate cancer, there is no subjective sensation at the early stage of the disease, and conditions such as hematuria and bone pain usually do not appear until the late stage. Although we have been able to detect the suspicious patients early through some auxiliary examinations, the definite diagnosis still requires the invasive “prostate puncture biopsy”. In clinical practice, it is a strange phenomenon that patients with suspected prostate cancer are not afraid of surgery, but are especially afraid of puncture biopsy. The most important thing is that they are not afraid of the surgery, but they are afraid of the puncture biopsy. There are often patients who have a significantly elevated prostate-specific antigen (PSA), a positive anal finger test, and an MRI that shows an occupied prostate, but they are still unwilling to undergo the puncture biopsy. As a result, the disease is delayed and some limited prostate cancer that could be cured metastasizes, causing extremely bad consequences and seriously affecting the prognosis and survival time of patients. For this reason, the Department of Urology at East China Hospital has been offering a new painless prostate puncture biopsy procedure since the beginning of this year, replacing the original local anesthesia and non-anesthesia via rectum with intravenous anesthesia, allowing patients to complete this invasive operation without pain, and achieving satisfactory results. The following is a brief introduction to prostate puncture biopsy, hoping that patients will gain from reading it and that some of them will be able to make up their minds about puncture. 1. What is a prostate puncture biopsy? When is it necessary? It is an invasive pathological examination performed by inserting a fine needle into the prostate gland to take material to confirm the diagnosis of prostate tissue disease. 2. Will prostate puncture biopsy cause tumor metastasis? Many patients have this concern, but according to the global literature and statistics, puncture biopsy does not cause implantation or metastasis in the puncture tract, so if the doctor recommends a biopsy, patients do not need to have this concern and should adopt a positive attitude. 3.What do I need to do before puncture? First of all, a blood test should be performed to determine whether there are contraindications to puncture such as thrombocytopenia and bleeding tendency. Patients who are taking drugs that affect coagulation, such as aspirin, poliovirus, or low molecular heparin, should stop taking them for more than a week before puncturing to avoid unnecessary bleeding, and an electrocardiogram is also necessary. Before the puncture, the health care provider will also provide relevant health education to the patient and family members and sign an informed consent form. 4.What do I need to pay attention to after the puncture? Generally, antibiotics and hemostatic drugs should be taken after the puncture procedure. Please try to get out of bed as little as possible on the same day, and do not use too much force for stool. Hematuria may occur after the operation, the first half of the urine is heavy, patients and family members do not need to be too nervous, hematuria symptoms can be gradually relieved within a week.