The liver plays a complex and crucial role in the metabolism of amino acids, sugars, lipids, and protein synthesis. The pathophysiological basis of diffuse liver disease is damage to one of these metabolic pathways. Substantial liver disease can be classified as accumulative, vascular and inflammatory lesions, and tomographic imaging of the liver plays an important role in its diagnosis, mainly MDCT (multidetector computed tomography) and MRI. The prominent role of MDCT is to clearly show the morphology of the liver, determine whether the lesion is diffuse or focal, and how it is anatomically related to adjacent organs. Because the detectors of multi-row CT can be arranged in various ways, either in the same width and spacing or asymmetrically, they produce different imaging methods and parameters. In addition to 64-row CT, other emerging techniques such as dual-source CT can also be used for CT scanning of the liver; liver MRI is also a comprehensive examination method to assess liver morphology and function, and with current technological advances and the application of new image analysis sequences, it is possible to perform liver screening with T1WI, T2WI, and diffusion-weighted (DWI). Three basic conditions need to be met for liver MRI: improved contrast of the liver parenchyma, reduced effect of respiratory motion and scan coverage of the entire liver.