Amoxicillin is an antibiotic of the penicillin class, whose main functions include antibacterial, anti-inflammatory and anti-infection, etc. It is mostly used for headache caused by infection of sensitive bacteria, and can achieve the purpose of treatment by killing bacteria, but amoxicillin itself does not have the effect of directly treating headache. In addition, there are many causes of headache, generally the use of amoxicillin alone can not achieve good treatment effect, but also need to cooperate with the following methods: 1. Avoid triggers: for example, emotional tension, eating certain irritating foods, such as garlic, chili, etc., drinking alcohol, forceful movements, frequent use of pain medication, etc., may trigger or aggravate the symptoms of headache, so patients pay attention to avoid such triggers; 2. Physiotherapy: Commonly used physiotherapy includes hot compress and physiotherapy for headache; 3.Medication: In addition to amoxicillin, there are many clinical drugs for symptomatic treatment of headache. For patients with mild headache, non-steroidal anti-inflammatory painkillers, such as aspirin and ibuprofen, are mainly used on a daily basis; however, for patients with intolerable headache, more potent painkillers such as tramadol and morphine can be used. However, most of the painkillers have the characteristics of dependence or addiction and may further aggravate the symptoms of headache when abused, so they should be taken correctly under the guidance of professional doctors. 4. Psychological guidance: For the long-term recurrent headache, some patients may have negative psychology such as anxiety and tension, so the surrounding family members and friends should persuade them to face it positively and optimistically and cooperate with the relevant treatment. In addition, some relaxing activities can be carried out, such as listening to soft music and taking a hot bath, in order to relieve the symptoms of headache to a certain extent.