For renal failure caused by drug overdose poisoning, the drugs causing renal failure should be stopped in time after the diagnosis is clear. Meanwhile, the drugs commonly used in the treatment of renal failure include diuretics such as furosemide, antihypertensive drugs such as nifedipine, and hormonal drugs such as methylprednisolone. If the patient has edema, diuretics such as torasemide or furosemide can be used to eliminate edema, and if the blood pressure is high, nifedipine or amlodipine can be used to control the blood pressure. If the kidney failure is related to connective tissue diseases, such as systemic lupus erythematosus or ANCA-associated vasculitis, hormones such as methylprednisolone need to be used to inhibit excessive immune responses in the body, thus protecting the kidneys. At the same time, adequate nutritional support should be given, and hemodialysis should be performed if necessary to normalize renal function as soon as possible. In the event of drug overdose poisoning leading to kidney failure, it is recommended to seek medical attention in time and choose the treatment under the guidance of a physician, do not take medication on your own.