(1) More than half of China’s people have been infected with hepatitis B: Hepatitis B patients, I am afraid that the most concerned about the virus to turn negative this topic, for this issue, can not simply use “can” or “can not” to answer. According to statistics, the total infection rate of hepatitis B virus in our population is more than 50%, that is, more than half of Chinese people have been invaded by hepatitis B virus in their lifetime, relatively speaking, less than 10% of hepatitis B surface antigen carriers. This is because most adults who are infected with hepatitis B virus have a self-limiting process, and the virus can be completely removed from their bodies without the use of antiviral drugs, and specific protective antibodies may be produced during the process of virus removal, which can prevent the body from being re-infected with hepatitis B virus. People with latent infection are even unaware that the hepatitis B virus has been cleared unknowingly, but several antibodies to the hepatitis B virus can be detected. These antibodies are often present in the body for many years, even for life. The vast majority of hepatitis B patients in China currently have chronic hepatitis B, which is still a disease that is difficult to cure completely. Therefore, whether from the presence of antibodies after infection, or the current difficult to completely overcome the chronic hepatitis, the propaganda of a drug can make all the hepatitis B negative is not credible. (2) chronic hepatitis B cure why so difficult: chronic hepatitis B cure is difficult for the following reasons: viral disease itself is a worldwide problem, so far mankind has not been able to apply to the hepatitis B virus exists inside the cells, the most in the liver cells, in addition to the liver cells, bone marrow, bile ducts, pancreatic liver cells in the nucleus of the hepatitis B virus covalent circular closed DNA (cccDNA) is replication The cccDNA can be used as a template for replication and constantly replicate new viral particles, and even the DNA of HBV DNA and hepatocytes may be integrated together, and the immune function of hepatitis B patients is often incompetent and in a state of immune tolerance or hypoimmunity. drugs, interferon and nucleoside (acid) analogs (such as lamivudine, adefovir, entecavir, and telbivudine), do not have the effect of completely killing the virus. Interferons mainly exert their antiviral effects indirectly by acting on certain immune cells and activating the antiviral and immunomodulatory effects of these cells. Another class of antiviral drugs, various nucleoside (acid) analogues, only act on a certain part of the virus replication cycle, and can only play a role in inhibiting the replication of the virus, but also cannot completely kill the virus.