Depression is a common psychological disorder worldwide, and many people with moderate to severe depression experience significant long-term effects on their daily lives. In the most severe cases, depression can lead to suicide. Many people who are unaware of depression assume that treatment for such a serious illness must be difficult or ineffective. The truth is that depression is not a disease that leaves doctors helpless. On the contrary, if diagnosed correctly and treated promptly, 80 to 90 percent of patients will achieve faster and more satisfactory results. Not only will they clear their gloom, but their ability to work and study, and social functions such as interpersonal communication will be the same as ever. For those patients with depression associated with physical illness, the control and improvement of depression will also enable patients to face reality with an optimistic and open-minded mood, restore their confidence in themselves and their future, increase their courage to overcome the disease, and facilitate their cooperation with medical personnel, and physical illness will recover faster and better as a result. In general, the treatment effect of depression is still satisfactory. Modern medical treatment for depression mainly consists of medication, psychotherapy and protective hospitalization. Most of the moderate and severe depressions are caused by the imbalance of some important neurotransmitters in the patient’s body, and these patients are mainly treated with antidepressant drugs during the acute phase. In the case of mild depression caused by external factors, the patient’s depression only has a minor impact on life and the patient has no obvious negative thoughts, so psychotherapy can generally have a more satisfactory treatment effect. Some severe cases, especially those with obvious negative intentions or behaviors, must be treated in a specialized hospital. Although there are proven treatments for depression, the objective reality is that less than half of patients worldwide (less than 10% in some countries) receive standardized and effective treatment. The diagnosis and treatment of depression is a social problem that has not yet been given widespread attention, and the reasons for this are: First, there is widespread discrimination against mental illness in society and patients’ low self-esteem. Many depressed patients are too embarrassed to seek medical treatment, and their families are unwilling to come to the psychology/psychosomatic medicine departments of hospitals even after repeated persuasion. Second, many patients do not realize that this is a disease and believe that they will get better after recuperating at home for a period of time, not knowing that depression is a disease that requires medication or psychotherapy; third, many non-psychiatry/psychosomatic medicine physicians in general hospitals have a low recognition rate of depression and do not pay enough attention to the psychological problems of patients with physical diseases. Fourth, there is a lack of trained mental health healthcare personnel to provide standardized treatment for depression. There are many depressed patients who are reluctant to receive antidepressant medication because they are worried about the side effects of antidepressants. In fact, the medications available for depression are much more advanced than in the past, especially with the introduction of many new drugs in the last 20 years or so. These drugs have very few side effects, are easy to take, do not make people dependent, and are safe for patients. Patients with depression can put all the worries about medication to rest.