With the accelerated pace of life and changes in eating habits, the incidence of gallstone disease is increasing and gallbladder removal patients range in age from teens to 80 years old, and cholecystectomy has become a common abdominal surgery. Many people have to ask if a person’s health will be affected after the removal of the gallbladder. The function of gallbladder is to store and concentrate bile. When the gallbladder has inflammation and stones, due to inflammation and edema of gallbladder wall and long-term stone stimulation, the wall of gallbladder becomes fibrotic and the concentration function is weakened or disappeared, and the ability of storing and concentrating bile is reduced due to infection and stones, and even purulent bile is formed, which causes damage to the body. “There is no need to keep a gallbladder with stones and inflammation. Removing the gallbladder can eliminate the resulting discomfort and risk of cancer. In addition, gallbladder polyps larger than 1 cm also require gallbladder removal. In clinical practice, we often see tragedies in which large stones are ignored by patients for a long time because they have no symptoms and are diagnosed with advanced gallbladder cancer. Of course, it is not necessary to remove the gallbladder even if there are gallstones, but it should be judged by the patient’s symptoms, medical history, stone size and the degree of chronic inflammation. Some people have mild diarrhea in the short term after gallbladder removal, which can be gradually compensated for by secretion from the liver and dilation of the common bile duct to compensate for the missing gallbladder function, and most diarrhea can diminish or disappear a few months after surgery. There is no clear evidence in evidence-based medicine that gallbladder removal can cause other diseases in the human body, and there is no evidence-based medical evidence for the claim that there is a high incidence of colon cancer after gallbladder removal, which has been explained in the current seven-year surgical textbook.