The treatment of neurosyphilis consists of two elements: the first is the treatment of the syphilis spirochete itself, and the second is the treatment of the corresponding complications. For the treatment of the syphilis spirochete itself, penicillin therapy is generally chosen. Penicillin can treat various types of syphilis, such as congenital syphilis, asymptomatic syphilis and neurosyphilis. When penicillin is used to treat neurosyphilis, the dose must be at a level that kills the syphilis spirochetes so that they are completely eliminated in the brain tissue, cerebrospinal fluid and spinal cord. There are generally two regimens, the first with penicillin G administered intravenously daily and the second with procaine penicillin administered intramuscularly daily. After the first, third, sixth, twelfth, eighteenth, twenty-fourth months and two years of anti-syphilis treatment, serum and cerebrospinal fluid routine and syphilis reaction need to be rechecked annually. If the results are abnormal, the examination should be continued for more than two years; if the disease is stable and the clinical symptoms have improved after three years, and the serological and cerebrospinal fluid syphilis reaction is normal, the neurological clinical examination and serological and cerebrospinal fluid syphilis reaction examination can be stopped. Symptomatic treatment is also some complications arising from syphilis invasion of the spinal cord, such as lightning-like pain, which can be treated with oral carbamazepine at 0.1g-0.2g three times a day; gastric crisis, which can be injected intramuscularly with 10mg of gastrodia; antipsychotic drugs for those with psychiatric symptoms; and antiepileptic drugs for those with epileptic seizures, which should be used according to their seizure types.