More than 90% of patients with neurosyphilis can have some clinical success with appropriate treatment, but patients with neurosyphilis complicated by optic nerve atrophy resulting in blindness are less likely to regain their vision. Neurosyphilis also causes stroke, meningitis, hearing loss, abnormal vision, dementia, and can lead to loss of pain and temperature sensation, as well as male sexual dysfunction and bladder incontinence. Neurosyphilis is a manifestation of stage III syphilis. If stage I syphilis or stage II syphilis is untreated or inadequately treated, 40% of patients can develop into stage III syphilis after 3-4 years. Although this stage is less contagious, it is very destructive, and in addition to skin and mucous membrane damage, skeletal syphilis, cardiovascular syphilis, and neurosyphilis can also occur, and stage III syphilis can be life-threatening.