Evidence related to nutritional metabolic deficiency disease lesions such as a history of malnutrition with niacin vitamin B1 and folic acid deficiency, signs and symptoms of nutritional metabolic deficiency leading to corresponding functional abnormalities, these can be used as diagnostic conditions for nutritional metabolic disease associated with psychiatric disorders. Clinical diagnosis of nutrient metabolism deficiency: 1. Vitamin B1 deficiency (thiamine deficiency) with psychiatric symptoms (1) Mental disorders: depressive state; governance disorder; disorders of consciousness can be manifested as hazy state occasionally delirium state. (2) Neurological symptoms: neuritis, nystagmus, dyscalculia and occasionally retinal hemorrhage. 2. Niacin deficiency with psychiatric disorders. (1) Mental disorders: ① neurasthenia syndrome: often appear in the early stage of the disease or milder ② depressive state: often accompanied by irritability and anxiety, self-blame and self-guilt attempts to suicide, etc. good to occur in the course of the disease. ③ nervousness syndrome: nervous excitement or nervousness stiffness similar to schizophrenia nervousness type of performance ④ disorders of consciousness: good to occur in the acute onset of the disease in the late stage of the disease patients can appear unconscious drowsiness, delirium, or confusion state can cause coma in serious cases high death rate is called niacin deficiency encephalopathy, when there are often neurological symptoms and features. ⑤ Chronic encephalopathy syndrome: Patients in the chronic phase may have slow reactions, memory, impaired calculating power, clumsy and slow movements, and in the late severe cases, Korsakoff syndrome or dementia may occasionally be seen. (6) A small number of patients may present with encephalopathy: clinical impairment of consciousness with severe neurological symptoms and signs. (2) Neurological symptoms: nystagmus, pupillary changes (pupil enlargement, blunted reflex to light), positive pyramidal tract sign hypertonia, abnormal sensory peripheral neuritis and epileptiform spasmodic seizures, deep sensory dyskinesia and ataxic dyskinesia if accompanied by subacute joint spinal cord degeneration. (3) Somatic symptoms: tongue inflammation, strawberry tongue; exfoliative dermatitis; gastrointestinal dysfunction. The diarrheal dermatitis is the most pronounced plus dementia is often referred to as a triple main sign complication of niacin deficiency.