1. Is this disease hereditary? If it is hereditary, why are there no other AS patients found in the family? Genetics accounts for 90% of the development of AS, which means that it is a genetic disease. However, in our clinic, only about 20-30% of patients are found to have AS in their family, which may be related to some genetic dominance and other characteristics. 2. What are the chances that the disease will be passed on to the next generation? I can only answer that if only one person in the family has the disease, the chances of the next generation appearing are less than if there are two or more patients in the family. 3, B27 (+) must be ankylosing spondylitis? In many local hospitals, when B27 (+) is found, it is concluded that AS is present, or when B27 (-) is ruled out, but this is wrong. In AS patients, only 90% of patients have B27 (+), while only 5-10% of the normal population with B27 (+) have AS. 4. AS is an immortal cancer? Whenever I hear my patients mention this phrase, I feel very heartbroken, because this phrase has made many AS patients lose their confidence and motivation to treat, so whenever I think of how many of them let their disease develop until they have spinal sclerosis and hunchback, and some of them with hip involvement can’t even walk in the end, it hurts. I hope that this phrase will never appear in our patients’ friends again. Here I would like to explain to you that although AS cannot be cured, it is a disease that can be controlled and the earlier it is treated, the better. Restriction of movement. These progressions can be delayed or even partially prevented by treatment. Therefore, there is a significant difference in prognosis between treatment and no treatment. 5, painkillers have a lot of side effects, can we take them when we are in pain, but not when we are not in pain? Many patients and friends, should have deep experience, when there is back pain, hip pain, eat a piece of painkillers (such as fenbid, mobic or futalin when) will feel a significant improvement in symptoms, and even pain disappeared, so after 1-3 months with a large proportion of patients will word or unconsciously stop these drugs, or irregular eating these drugs, and pain when eating, not pain, do not eat. There are many reasons for not taking them, including the fear of side effects, so they do not want to take them. This is the most common reason. But what I would like to suggest to my fellow patients is that pain medication is not simply a pain reliever, it is a medical name for a non-steroidal anti-inflammatory drug (NSAID), which in addition to pain relief also has anti-inflammatory effects, and in the treatment of AS, adherence to daily dosing has the effect of slowing or stopping the progression of spinal ossification on X-rays (there have been 2 years of studies to show this). So my answer is that depending on each patient’s condition, when a specialist recommends that you adhere to a daily NSAID, please be sure to follow the doctor’s orders. As for the side effects, I believe that each doctor will give you advice only after weighing the pros and cons, and they will also be treating your disease while also testing your response to the medication (including side effects). 6. Do I have to take medication for the rest of my life for AS? I can’t give a specific answer to this question because each patient’s situation is different and the specific treatment is different. However, I need to clarify one point here: in clinical practice, about 60-70% of AS patients will gradually enter the stabilization phase after the age of 40, that is, the activity of the disease will gradually decrease, that is, the symptoms will slowly decrease and the disease will almost stabilize. Therefore, some patients can slowly change the dosage and usage of medication after the age of 40, depending on the situation, or even discontinue the medication, as the disease is more stable and the body function is better preserved. 7.What about physical exercise for this disease? In this disease, physical exercise has a very important therapeutic role to play, adhere to the exercise, can slow down the process of spinal ossification, try to maintain the patient’s collective function, but the method of exercise and the intensity of grasp is also very important, too strenuous exercise is also not suitable for AS patients, especially in the active and late stage of AS patients. The easiest and most recommended exercise is breaststroke. 8.What symptoms indicate a poor prognosis? (1) The younger the onset of the disease, the faster the disease progresses and the prognosis is poor if not treated in time. (2) Hip joint involvement, the hip is the most important joint in the human body to support walking and other functions, hip joint involvement, if not timely and effective treatment, can lead to hip joint fusion, necrosis, and eventually can not walk, squatting, only hip replacement. 9.What should I do if I have AS? When patients are first diagnosed with AS, many people often have such a thought, but I hope each patient knows that the patient rate of this disease is very high, about 0.3-0.5% in China, that is to say, not 1000 people have 3-5 people have this disease, but when you find out that you have this disease, at the same time will be the beginning of your treatment of this disease, but for those who are not diagnosed But for those who are undiagnosed, you are still lucky that at least you are aware of the disease and you are about to start treatment. After the appropriate treatment, you can live your life as normal. 10.What physical exercises can we do then? These sports can be, but should try to avoid too strenuous, and also in sports, try to avoid injury, otherwise if it is a sprain, people without AS can generally recover in a week, but patients with AS may take 1 month, or even longer for the joint to swell down. 11.What should I pay attention to in terms of diet for this disease? In theory, there is no dietary contraindication for AS patients.