The duration of an acute attack of gout is variable, as there is a great deal of individual variation. In most patients, the pain lasts about three to five days, and in milder cases, the joint pain can be relieved significantly within a day, and in longer cases, usually within 2 weeks. However, in patients with advanced age, long duration of disease, frequent acute gout attacks, and gout stones, gout attacks can last for more than a month or even longer. Long-term hyperuricemia can cause uric acid crystals to be deposited in the joints, triggering acute inflammation of the joints and symptoms such as redness, swelling and heat in the joints. At this time, the number of leukocytes in the synovial fluid increases significantly and engulfs the urate crystals, while releasing a large number of inflammatory factors, so the patient not only has a heavy inflammatory response in the joints, but also often induces a systemic inflammatory response and a series of manifestations such as fever. In patients stimulated by acute inflammatory response, the body is in a state of stress, on the one hand, the body accelerates the excretion of uric acid, on the other hand, the secretion of adrenal hormones increases, these are conducive to inhibit the acute inflammatory response. In addition, during an acute attack of gout, patients tend to drink a lot of water, which can dilute the urate concentration in the blood, and at the same time, with the increase in urine volume uric acid excretion also increases, which can also alleviate the inflammatory response to a certain extent. Therefore, in patients with acute gout, even if they do not take medication, the joint symptoms can be relieved on their own within a few days or 2 weeks, or even disappear. It is important to note that although acute attacks of gout can be self-relieving, they are mostly seen in patients with a short history of first attacks. In patients with a long history of frequent attacks, the inflammation of the joints during an acute gout attack not only does not resolve on its own, but even gets progressively worse and must be reduced by drug intervention.