Glutathione is a metabolic enzyme in the body that can come from muscle tissue or from the liver. Glutathione is the main reference indicator in liver function tests. If liver function is impaired, this indicator can appear significantly elevated, and the clinical symptoms are mainly nausea, anorexia, and fatigue, etc. Common clinical diseases include drug-related liver damage, alcoholic liver disease, viral hepatitis, fatty liver, autoimmune liver disease, etc. The normal range of glutamic oxalacetic transaminase is 0-40U/L. 50U/L is a mild increase, which usually does not affect the normal life activities of the body if there is no underlying liver disease. Glutathione is easily affected by physical status, such as strenuous exercise, staying up late, fatigue and weakness, recent excessive alcohol consumption, eating fatty food, etc., which can lead to a mild increase in glutathione and usually does not require clinical treatment. Therefore, the presence of a mild increase in glutamic oxalacetic aminotransferase should be analyzed according to the appropriate etiology for each case and treated accordingly if necessary. The management of glutathione is different depending on the cause of the injury. If the elevated glutathione is caused by exercise, it can be recovered quickly with conditioning, a light diet with little salt and regular rest and relaxation. If there is a history of liver disease, such as viral hepatitis and cirrhosis, you should be checked for the presence of disease recurrence.