Liver transplantation is an effective treatment for end-stage liver disease, which started in the 1950s and has a history of more than 50 years. After four stages of experimentation, trial, application and development, it has been widely carried out in foreign countries in the 1980s. In China, since the late 1990s, especially in recent years, clinical liver transplantation has been widely carried out, the number of transplants has increased substantially every year, and the near- and long-term efficacy of transplantation has been improving. Since the 1990s, I have been following the development of liver transplantation at home and abroad, and at the same time making comprehensive preparations for the development of this technology, and have successfully completed the first clinical liver transplantation in 2004 with good results. In order to better carry out liver transplantation and relieve the suffering of liver disease patients, our medical and nursing staff will do their best to do this work. Huang Gang, Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Guangzhou Medical University Indications for Orthotopic Liver Transplantation (OLT) The main indications are congenital biliary atresia and congenital hepatic metabolic deficiency in children, and various types of end-stage hepatitis and cirrhosis and primary liver cancer in adults.1. End-stage cirrhosis The first indication is end-stage cirrhosis due to various causes, including post-hepatitis cirrhosis, primary biliary cirrhosis, post-necrotic cirrhosis, cirrhosis due to primary sclerosing cholangitis and alcoholic cirrhosis, etc. 2. congenital disorders of hepatic metabolism are rare diseases of young children, including hepatomegaly (Wilson’s disease), tyrosinemia, α1-antitrypsin deficiency, neurological Myelin phospholipid accumulation disorder (Niemann-Pick disease), galactosemia, hepatic glycogen storage disorders type I and IV, hyperlipoproteinemia type II, neonatal congenital nonhemolytic jaundice (Crigler-Najjar syndrome), phenylketonuria, aquamarine histiocyte syndrome, severe compound immunodeficiency, urea cycle enzyme deficiency, and hemophilia A or B. 3. Congenital Biliary atresia liver transplantation is indicated for total biliary atresia, i.e. congenital bile duct loss, where a hepatic portal-jejunostomy (Kasai) cannot be performed. 4. chronic aggressive hepatitis including chronic viral hepatitis B, with hepatitis C or simple chronic hepatitis C. 5. acute or subacute liver failure acute or subacute liver failure caused by various causes (such as viruses, drugs or toxins). 6. Liver tumors Benign tumors such as giant hepatic hemangioma, multiple hepatic adenomatosis, multiple hepatic cysts, etc. Malignant tumors such as primary hepatocellular carcinoma, metastatic carcinoma confined to the liver whose primary focus has been eradicated, cholangiocarcinoma, hemangioendothelial sarcoma, smooth muscle sarcoma, hilar cholangiocarcinoma (Klatskin carcinoma), hepatic fibrous lamellar carcinoma, etc. 7. Budd-Chiari syndrome Superior and inferior hepatic vena cava obstruction with progressive hepatic insufficiency without coagulation disorders or myelogenesis, especially when hepatic phlebitis occurs Initial liver transplantation failure includes complications such as preservation failure, severe rejection crisis, hepatic artery thrombosis, and post-transplantation infection. The 5-year survival rate of repeat liver transplantation is 50%. Address: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou Medical College, No. 151 Yanjiang Road, Guangzhou, China Contact: 13710854269