Depressive episodes are dominated by a depressed mood, which is not proportional to its situation and can range from moping to grief and even malaise. In severe cases, psychotic symptoms such as hallucinations and delusions may occur. In some cases, anxiety and motor agitation are significant. Symptom Criteria】Mainly depressed mood with at least four of the following: 1. loss of interest, no sense of pleasure; 2. loss of energy or fatigue; 3. psychomotor retardation or agitation; 4. low self-esteem, self-blame, or feelings of guilt; 5. difficulty in association or reduced ability to think; 6. recurrent thoughts of death or suicidal or self-injurious behavior; 7. sleep disorders, such as insomnia, early awakening, or 7. Sleep disorders, such as insomnia, early awakening, or excessive sleep; 8. decreased appetite or significant weight loss; 9. decreased sexual desire. Severity Criteria】 Impaired social function, causing pain or adverse consequences to the person. Criteria for the course of the disease] 1. Meet the criteria for symptoms and severity for at least 2 weeks. 2.Some schizophrenic symptoms may exist, but do not meet the diagnosis of schizophrenia. If the symptom criteria of schizophrenia are also met, the depressive episode criteria are met for at least 2 weeks after the schizophrenic symptoms have resolved. [Exclusion criteria] Exclude organic mental disorders, or depression due to psychoactive substances and non-addictive substances.