At present, the two main categories of hepatitis B antiviral treatment are interferon and nucleoside analogues. If you are a woman of childbearing age with hepatitis B, it is best not to use these two categories of antiviral drugs during pregnancy, of which interferon is contraindicated, tibivudine and lamivudine among the nucleoside analogues belong to reproductive safety category B drugs and can be used cautiously for pregnant women with hepatitis B. The other varieties of nucleoside analogues belong to category C and cannot be used for pregnant women. As for male hepatitis B patients, there is no clear statement. In general, male hepatitis B patients treated with interferon or nucleoside analogs can have their wives become pregnant during treatment because animal studies with interferon have not shown any adverse effects on the fertility of male animals, and male rhesus monkeys treated with interferon alpha-2a at doses up to 25 x 106 IU/kg body weight/day for up to 5 months have not been affected in terms of fertility. To date, no effects of nucleoside (acid) analogs on male sperm development have been observed, so male patients treated with nucleoside (acid) analogs do not affect their wives’ fertility and do not need to discontinue the drug midway to avoid relapse of the disease.