Acetaminophen tablets belong to the aniline class of antipyretic analgesics, also known as paracetamol, and are a widely used over-the-counter class of antipyretic analgesics. The main side effects of acetaminophen are occasional rash, urticaria, drug fever, thrombocytopenia, and leukopenia (e.g., granulocytopenia). Prolonged heavy use can lead to liver failure. [1] Adverse reactions at regular doses are rare, including nausea, vomiting, sweating, abdominal pain, and skin pallor. The analysis of 29 cases of adverse reactions caused by acetaminophen revealed that the main side effects were allergic reactions, with a percentage of 44.8%; hepatic and renal impairment, with a percentage of 20.7%; hematologic system, with a percentage of 10.3%; digestive system, with a percentage of 6.9%; circulatory system, with a percentage of 6.9%; and other, with a percentage of 10.3%. During the use of the drug, it should not be used for more than 3 consecutive days for the relief of fever and for more than 5 days for pain relief, since the main purpose of administration is symptomatic treatment. Use with caution in patients with aspirin allergy, do not take drugs containing antipyretic and analgesic drugs at the same time (such as certain compound cold medicines), and be alert to acute drug-related liver injury caused by overdose of acetaminophen. Use with caution in patients with hepatic or renal insufficiency.