It is a kind of antibacterial alkaloid extracted from the plants of the family Berberaceae, such as Huang Lian and Huang Cai, which can fight against pathogenic microorganisms and has an inhibitory effect on many kinds of bacteria such as Mycobacterium dysenteriae, Mycobacterium tuberculosis, Mycobacterium pneumoniae, Mycobacterium typhi and Mycobacterium diphtheriae. However, people do not recognize that safranin is an antibacterial agent, and it is harmful to health to take it indiscriminately for diarrhea, so it is necessary to recognize safranin again, apply it accurately and manage its use strictly in today’s world of antibacterial abuse. Modern medical research has found that there are more than 600 species and 100 trillion of huge flora system in the human intestine, and these symbiotic bacteria influence our health and life. Without them, human beings cannot survive healthily because they can synthesize various essential vitamins that our body cannot synthesize by itself, and short-chain fatty acids such as butyric acid that are necessary for the regeneration and repair of our intestinal mucosa, and especially importantly, these intestinal microorganisms are also important members of our intestinal lymphatic immune system, which accounts for 70% of our body’s immune function system. Long-term abuse of flavopiridol will cause incalculable damage to the above system. The causes of diarrhea are numerous and can be divided into infectious and non-infectious diarrhea, with infectious diarrhea being mostly acute and non-infectious diarrhea being mostly chronic. Flavopiridol is only indicated for infectious diarrhea. The manifestation of gastrointestinal infection can be mild or severe; in mild cases, there is only abdominal pain and diarrhea; in severe cases, there will be nausea, vomiting, fever and chills, loss of appetite, leading to dehydration, acidosis and shock in severe cases. Generally speaking, for light inflammation, flavopiridol can be used, but also according to the control of inflammation, the right amount of the right time to use, for heavy must be combined with anti-infective effect of strong antibacterial agents. Currently recognized diseases such as irritable bowel syndrome, ulcerative colitis, malnutrition, endocrine diseases, allergic diseases, etc., can lead to chronic diarrhea, for this non-infectious diarrhea, safranin is useless, not only useless but also harmful, the defenders of our intestinal health – intestinal flora will be destroyed, and over time can It will lead to dysbiosis of intestinal flora, especially the lack of intestinal butyric acid-producing bacteria, which will cause intestinal mucosa regeneration and repair obstacles, increased mucosal permeability, and the selective absorption function of the intestine will be reduced or lost, thus allowing a large number of pathogenic bacteria or harmful substances to enter, further triggering inflammation and immune dysfunction, leading to diarrhea and irritable bowel syndrome in mild cases, and intestinal cancer and intestinal disease complications in the long term. Huanglian is a chemically synthesized drug, not a Chinese medicine. For diarrhea identified by traditional Chinese medicine as spleen and stomach deficiency cold, Huanglian is bitter and cold, but it is easy to hurt the spleen and stomach, damage the gastrointestinal function, more likely to appear stomach pain, nausea and other digestive symptoms, aggravating the condition. Therefore, for the unexplained diarrhea can not take Huanglianxin at will, it is best to choose according to the hospital stool, blood test, general diarrhea 1-2 times without other accompanying symptoms such as diet, water and soil caused by factors such as, in fact, do not need to take Huanglianxin, maintain a light diet, the body can recover on its own, but recurrent episodes should identify the cause.