Depression is a common mood disorder with significant and persistent mood depression as the main symptom, accompanied by corresponding changes in thinking and behavior. It is not difficult to diagnose depression, but the patient’s performance is not typical, as the core depressive symptoms, often hidden in other psychological and physical symptoms, contained but not revealed, thus easily lead to doctors misdiagnosis, failure to treat, and even serious consequences. You should be alert to some of the following alarm signals: 1, people are not happy when they are happy. Often for some small things, even for no reason to feel bitter, sad frown. 2, the past hobbies, and even hobbies, as well as daily activities have lost interest, and all day lethargy. 3.Life becomes lazy, unkempt, easy-going and unmotivated. 4.Long-term insomnia, especially characterized by early awakening, lasting for weeks or even months. 5.Thinking reaction becomes sluggish, and it is difficult to make a decision when things go wrong. 6.Always feel inferior, often blame themselves, always regret about the past, and lose confidence in the future. 7.Sensitive and suspicious, always suspecting that they have a serious illness, although constantly conducting various tests, but still difficult to release their doubts. 8.Loss of memory, often lose things. 9.Temper becomes bad, impatient and irritable, difficult to concentrate. 10.Often feel panic and anxiety for no apparent reason. 11.Frequent anorexia, nausea, bloating or diarrhea, or symptoms such as stomach pain, but no obvious organic changes during examination. 12.Some patients have no obvious reason for loss of appetite and weight loss. 13.Frequent fatigue, lack of energy and incompetence in doing things. 14.Mental indifference, it is difficult to take interest in everything around, and do not want to talk or do anything. 15.Self-perceived headache, back pain, body pain, but no organic cause can be found. 16.Significantly reduced social activities, reluctance to communicate with friends and relatives, and even closed doors. 17.Loss of interest in sexual life. 18, often involuntarily feel empty, they feel no value and meaning of survival. 19, often think of topics related to death. The above 19, if there is a particularly serious, or several at the same time, it is likely to be a sign of depression, must be vigilant. Most depressed patients also have physical symptoms, such as sleep disturbances, pain, fatigue, stomach discomfort, poor appetite, panic and shortness of breath, as well as symptoms of various systems. Patients with insidious depression often do not have typical symptoms such as depressed mood, but have predominantly somatic complaints. It is characterized by headaches and insomnia, especially early awakening, although there are many symptoms. In addition, there is a circadian rhythm of heavy day and light night, as well as a seasonal pattern of heavy in spring and autumn but light in summer, and there is mostly anxiety, and anxiety symptoms are aggravated during menstruation in female patients.