Hepatitis B virus-associated nephritis (HBV-GN), is an immune-complex glomerulonephritis caused by chronic hepatitis B virus (HBV) infection.In 1971 Combes reported hepatitis B-associated membranous nephropathy for the first time, and in 1989, the Beijing Symposium recommended the diagnostic conditions of HBV-GN in China. In our country HBV infection rate is 9.8%, causing renal damage there is no reliable data. At present, western medicine treats HBV-GN mainly with antiviral and selective immunosuppressant therapy. However, immunosuppressants may promote HBV replication and aggravate liver damage, and some antiviral drugs have drug resistance. Chinese medicine treatment of HBV-GN has the advantages of regulating the immune system, reducing proteinuria, and alleviating liver and kidney damage. 1. TCM’s understanding of the pathogenesis of HBV-GN. Prof. Zhang Qi, a master of Chinese medicine, believes that the pathogenesis of HBV-GN is spleen deficiency and obstruction by dampness and toxin in the liver meridian. Prof. Liu Yuning believes that dampness, heat, and toxin stagnate the liver and kidney. Prof. Shao Zhaodi believes that the deficiency of positive qi, external dampness-heat evil poison, internalized in the liver, injected into the kidney, damage to the collaterals, and become stagnation for a long period of time. Li Suliang discusses the HBV-GN transmission law that: at the beginning of the disease, with dampness, heat and turbid toxin in the kidney, blocking the qi of the standard reality, followed by the blood not smooth into the silt, dampness, heat and turbid toxin intertwined, for a long time will be depletion of gas, resulting in qi, blood, yin and yang of the deficiency. Prof. Wang Yaoxian believes that this disease is caused by insufficiency of the spleen and kidney, invasion of dampness and toxin, and positive deficiency and blockage. Summarizing the views of various schools of thought, it is believed that: the deficiency is “deficiency of the liver, spleen and kidney”, and the deficiency is “dampness and heat, depression and silt”. 2. Chinese medicine treatment (1). Diagnosis and treatment: Prof. Shao Zhaodi from the 8 types of treatment: ① damp-heat accumulation type with Yin Chen Wu Ling San plus reduction; ② heat and toxicity blazing type with Rhinoceros Jiao Di Huang Tang plus reduction; ③ Liver Depression and Spleen Deficiency type with Free and Easy San plus reduction; ④ qi stagnation and dampness obstruction type with Chai Hu Shuo Hepatophoresisan plus reduction; ⑤ qi and blood stasis type with tonify the middle and benefit the Qi Tang plus blood products; ⑥ liver and kidney deficiency type Qiju Di Huang Tang and Mai Wei Di Huang Tang combined with the Er Zhi Pill; ⑦ Spleen and kidney Yang Deficiency type with Zhenwu Tang and The real spleen drink; ⑧ qi and yin deficiency type with six flavors of dihuang soup and pulse shengwu san. Each type of inconsistency, the use of different drugs, can not be listed here. However, in the last 10 years, the literature on TCM treatment of HBV-GN has been analyzed, and the results are as follows: ① Frequency of TCM evidence: 20 pieces of statistical literature, according to the frequency of the evidence is sorted as follows: Damp-heat internal evidence (including liver and gallbladder damp-heat, damp-heat and venomous, 20 times); Liver and kidney yin-deficiency (19 times); Liver-depression and spleen-deficiency evidence (16 times); Spleen and kidney yang deficiency evidence (including yang-deficiency and watery flooding, 8 times); Blood stasis and toxicity interconnections (including wet and silt obstruction, 6 times); Blood stasis and toxicity (including wet and silt obstruction, 6 times); Blood stasis and toxicity (including wet and silt obstruction). (6 times); Qi stagnation and blood stasis (including Zheng deficiency and blood stasis, kidney complex stasis, and Qi stagnation and dampness obstruction, 6 times); Qi and yin deficiency (4 times); and heat and toxicity blazing (3 times). If the typing is simplified, more than half of them are Damp-Heat Internalized Symptoms, Liver and Kidney Yin Deficiency Symptoms and Liver Depression and Spleen Deficiency Symptoms. ②Frequency of prescription: Six-flavored Di Huang Tang (10 times); Zhen Wu Tang (8 times); Yin Chen Wu Ling San (6 times); Tao Hong Si Wu Tang (6 times); Huang Lian Xie Du Tang (4 times); Real Spleen Drink (4 times); Shen Qi Di Huang Tang (3 times); Free and Easy San (3 times); Zhi Bai Di Huang Tang (3 times); Chai Hu Shuo Hepatitis San (3 times); Wu Ling San (3 times). 中药频次：茯苓(25) ,黄芪(18),白术(17),丹参(17),生地(14),柴胡(13),山药(13),甘草(13),白花蛇舌草(12), 茵陈(12)，牡丹皮(11)，泽泻(11)，当归(10)，杜仲(10)，栀子(10)，党参(10)，益母草(9),白芍 (9),Cortex Eucommiae (9). (2). Monotherapy:Hou Chunsheng found that Astragalus can enhance T-cell function, promote interferon secretion, promote the repair of ischemia-reperfusion glomerular injury, reduce renal histopathological damage, and combined with thymidine can reduce urinary protein in patients with HBV-GN, and can significantly elevate serum albumin levels. Li Lin et al. reused cornelian cherry meat to treat 32 cases of HBV-GN, HBV virus titer decreased and proteinuria was significantly reduced after treatment. Liu Jie et al. treated 32 cases of HBV-GN by combining huangkui with bitter ginseng, 24h urine protein, BUN, Scr decreased significantly after 12 weeks of medication, and serum albumin increased significantly, which is considered that huangkui combined with bitter ginseng has good effect in treating HBV-GN. 3.Combination of traditional Chinese and western medicine Wang Hua used Matemacrolate (MMF) initial dose of 1.0 ~ 1.5g / d, 2 / day, 6 months later reduced to 0.75 ~ 1.0g / d, in the MMF at the same time morning tonic entegravir (ETV) 0.4mg, Prednisone 0.4mg / kg / d, 12 weeks after the gradual reduction of dosage. And with the main formula of Liver and Kidney Cleansing Drink, add or subtract according to the symptoms. The following formula was added and subtracted according to the symptoms: 20g of Radix et Rhizoma Alba, 15g of Salviae Miltiorrhizae, 12g of Radix Paeoniae Alba, 10g of Radix Chasteberry, 10g of Radix Aristolochiae, 15g of Lycium barbarum, 12g of Rhizoma Cymbopogonis, 15g of Radix Panax Quinquefolii, 20g of Astragalus membranaceus, 15g of Radix et Rhizoma Poriae, 15g of Radix et Rhizoma Polygonati Odorati, 15g of Rhizoma Chrysanthemum officinale, 6g of Radix glycyrrhiza. 0.01). Meng Xiangang used Ganlixin capsule 150mg, 3/day, severe cases of static Ganlixin 150mg, Atomolan 1.2g, 1/day, HBV replication-positive people were given α-interferon, 3 million units, 1 time/every other day, 3 months as a course of treatment, the treatment group in the control group based on the addition of Yi Liver and Kidney Soup treatment, one dose per day, boiled water, the course of treatment for 3 months. Composition: Salvia miltiorrhiza 30g, Radix et Rhizoma Ginseng 20g, Rhizoma Atractylodis Macrocephalae 25g, Fructus Schisandrae Chinensis 15g, Rhizoma Coptidis Macrocephalae 30g, Radix Astragali 30g, Radix Achyranthis Bidentatae 10g, Poria 15g, Radix Achyranthis Bidentatae 10g, Glycyrrhiza Uralensis 6g. Of the 33 cases in the treatment group, 3 cases were clinically cured, 11 cases showed obvious effect, 10 cases were effective and 2 cases were ineffective, the total effective rate was 93.94%, and the effective rate of the control group was 72.73%. 4. Problems and challenges (1). Some TCM literature lacks the diagnostic basis of nephropathology, and some of the studied cases are not necessarily HBV-GN.(2). Most of the medical practitioners use medicines based on their own experience, and the papers on clinical research lack randomized double-blind controlled studies, not to mention multi-center large-sample clinical studies. (3). The identification and typing of various schools is not uniform, the objectification of symptoms is not consistent, and there is no uniform standard for assessing the efficacy. Therefore, in the future, it is necessary to have a clear diagnosis of renal pathology, formulate recognized typing criteria and efficacy assessment standards, introduce evidence-based medicine methods, conduct multicenter large-sample randomized double-blind controlled studies, and optimize an effective protocol for the treatment of HBV-GN with Chinese medicine.