White lesions of the vulva are a group of chronic diseases in which degeneration and pigmentation of the female vulvar skin occur, the cause of which is still unknown, characterized by strange itching of the vulva, whitening of the lesioned skin, thickening or thinning of the skin, loss of elasticity or ulceration. The pathological changes are in the dermis, and the epidermal lesions are secondary and often persistent, seriously affecting women’s lives. Etiology and pathology of white vulvar lesions In recent years, it has been found that microangiopathy in the dermis triggers degenerative changes in the epidermis, which may constitute an important pathophysiological mechanism of the disease. In the disease state, there are obvious pathological features such as cell degeneration, loss of melanocytes, different degrees of leukocyte and lymphocyte infiltration, capillary occlusion in the dermis, microvascular disorders and collagen fiber production disorders in the epidermis and dermis, among which capillary occlusion leading to local nutritional dysfunction may be the central link. Focused ultrasound therapy is a new non-invasive therapeutic technique developed in recent years, using the good energy penetration and deposition of ultrasound in tissues, which can be focused into the dermis of the skin, exerting its thermal and cavitation effects, and can promote the neovascularization and recasting of microvessels. Increase the permeability of vascular endothelial cell membrane, improve the nutritional status of microvessels and nerve endings; change the microenvironment of local tissue growth, enable tissue repair and regeneration, so as to achieve the purpose of rehabilitation of diseased skin. Ultrasound treatment of white vulvar lesions is safe, effective, quick recovery, less painful and easy for patients to accept. There is a relationship between the type of white vulvar lesions and the dose of ultrasound treatment. In hyperplastic cases, the treatment time per unit area is slightly longer and the dose is more; in atrophic cases, the treatment time per unit area is shorter and the dose is less. The sensitivity of different tissues to ultrasound is different. At the same treatment dose, the lesioned tissue will first be irreversibly damaged by the impact of ultrasound and the normal tissue will be reversibly damaged, and the tissue can be repaired normally after treatment.