The etiology of cerebral atrophy is complex, and the pathogenesis has not been fully elucidated, so there is still a lack of effective therapeutic measures to improve clinical symptoms and slow down the progression of the disease, of which pharmacotherapy is widely used. The drug treatment of cerebral atrophy mainly includes the following categories: 1, brain metabolism activator: the application of olanzapine, nimodipine, nicergoline and other drugs to improve microcirculation and promote brain metabolism to treat neurological deficits, memory and intellectual impairment caused by cerebral atrophy. 2, improve cognitive function drugs: different types of cerebral atrophy patients can appear memory loss, slow reaction and other dementia performance, clinically can be cholinesterase inhibitors, such as donepezil, cabalatine, etc. to increase the concentration of acetylcholine in the brain, to improve memory, improve the role of the patient’s cognitive function. It can also be used to reduce neuronal damage in the brain by applying excitatory amino acid receptor antagonists such as meperidine to slow down the progress of the disease. 3, symptomatic treatment drugs: if patients appear anxiety, depression and other psychiatric symptoms can be added symptomatically with Valium, anti-anxiety, depressants, etc. to control patients’ psychiatric symptoms; if patients appear tremor, motor retardation and other symptoms can be added symptomatic treatment with levodopa, etc. 4, Chinese medicine, Chinese medicine treatment: for some patients with cerebral atrophy in Chinese medicine based on the identification of evidence, blood circulation, blood nourishing, nourishing the blood, add Jin to nourish the marrow and other soup treatment can be to a certain extent on the patient’s symptoms, delaying the progress of the disease. In summary, drug therapy is currently the main treatment for cerebral atrophy, but cerebral atrophy still lacks effective means of cure, still to play the above-mentioned drugs to improve clinical symptoms and delay the progress of the disease mainly.