Cerebral atrophy is a complex condition, and there is still a lack of effective curative measures and no best therapeutic drugs, mainly based on the type of symptoms of patients to choose the appropriate drugs to improve the patient’s symptoms and delay the progress of the disease. At present, the treatment drugs for cerebral atrophy mainly include the following categories: first, brain metabolism activators: such as Olanzapine, Nimodipine, Nicergoline and other drugs can improve microcirculation, promote brain metabolism, treatment of neurological deficits caused by cerebral atrophy, memory and intellectual impairment. Second, improve cognitive function drugs: different types of cerebral atrophy patients can appear memory loss, slow reaction and other dementia performance, clinical cholinesterase inhibitors, such as donepezil, cabalactin, etc. to increase the concentration of acetylcholine in the brain, to improve memory, improve the role of the patient’s cognitive function. Excitatory amino acid receptor antagonists such as meperidine can also be applied to reduce neuronal damage in the brain to slow down the progress of the disease. The third category, symptomatic treatment drugs: if patients appear anxiety, depression and other psychiatric symptoms, anti-anxiety and depression drugs can be added to control patients’ psychiatric symptoms; if patients appear tremor, motor retardation and other symptoms, levodopa can be added to symptomatic treatment, etc. Fourth category, Chinese medicine, Chinese herbal medicine treatment: for some patients with cerebral atrophy in Chinese medicine on the basis of identification, blood circulation, blood nourishment, nourishing qi and marrow and other tonics can be used to a certain extent on the patient’s symptoms, delaying the progress of the disease. Therefore, cerebral atrophy should be based on the type of symptoms of patients to choose the appropriate drug therapy, patients should adhere to treatment, timely follow-up, adjust treatment, and can not hope for a particular best drug.