Lorazepam tablets are a benzodiazepine sedative that is used clinically to stabilize patients’ mood, reduce anxiety and tension, and improve sleep. If overdosed, it can cause toxic reactions. Patients first appear with gastrointestinal symptoms, such as burning sensation in the stomach area, nausea, vomiting, abdominal pain, diarrhea and other gastrointestinal irritation symptoms. As the drug is gradually absorbed in the body, it can inhibit the central nervous system, cardiovascular and respiratory systems, resulting in drowsiness, dizziness, weakness, uncoordinated body movements, slurred speech, drowsiness, coma and confusion, etc. In severe cases, blood pressure may drop, respiratory depression and even apnea. Especially in elderly people, after overdose of such sedatives, asphyxia, cyanosis of mouth and lips, weakened corneal reflex, deep coma, and inability to swallow due to excessive oropharyngeal secretions and accidental aspiration to the lungs can cause adverse complications such as aspiration pneumonia. Therefore, an overdose of lorazepam tablets should be followed by a prompt visit to the hospital, and if the patient is conscious, he or she should be induced to vomit as soon as possible. Comatose patients need to be given gastric lavage disposal as soon as possible, and blood perfusion therapy should be given as soon as possible to promote the excretion of toxic substances from the body. Establish intravenous access, give a lot of rehydration diuresis, apply antagonists such as flumazenil to antagonize the side effects of the drug, and for those with decreased blood pressure need to be given antihypertensive treatment, and those with respiratory failure are given ventilator-assisted ventilation to save the patient’s life and minimize adverse effects.