Acute hemolysis is commonly caused by transfusion of blood due to blood group incompatibility, or by problems in the storage or transportation of blood products. Symptoms of acute hemolysis include: during the beginning of transfusion or within a short time after transfusion, the patient suddenly develops chills, chills, high fever, back pain, sometimes hemoglobinuria, like soy sauce, and in severe cases, urinary closure, acute renal failure, and in the most serious cases, diffuse intravascular coagulation, the patient shows a drop in blood pressure, cold extremities, and small skin patches on the extremities. The most effective way is to stop blood transfusion immediately, give oxygen to the patient, monitor vital signs, rehydrate heavily, and ensure urine output. If the patient’s blood pressure decreases, anti-shock treatment is also given, and if necessary, plasma replacement therapy is also given to maintain kidney function. Therefore, acute hemolysis is a clinical emergency that requires active management.