Once intrahepatic metastases appear in liver cancer, it is stage IV liver cancer or advanced liver cancer. The main treatment for advanced liver cancer is targeted therapy, and a few patients in good health can use chemotherapy. Targeted therapies are mainly anti-tumor angiogenesis drugs such as sorafenib, regrafinib, lenvatinib, etc. These targeted drugs have been shown through research to extend progression-free survival time, that is, to extend life expectancy. Of course, immune checkpoint inhibitors, at present, can also be used for the treatment of advanced primary hepatocellular carcinoma. In conclusion, once intrahepatic metastasis occurs in liver cancer, it is a very poor prognosis, and there is no way to cure liver cancer through radical surgical resection.