Bipolar disorder acute treatment: Bipolar mania: Medication mainly includes classical mind stabilizers and second-generation antipsychotics and some classical antipsychotics, classical mind stabilizers mainly include lithium carbonate, valproate, carbamazepine, more and more studies in recent years as well as more and more rigorous study designs are used to evaluate the efficacy of antipsychotics, especially second-generation antipsychotics, in treating manic episodes, and the study The results confirm the rapid onset and efficacy of antipsychotics for the treatment of mania compared to classical mind stabilizers, and the higher safety profile of atypical antipsychotics. The Canadian Alliance for Mood and Anxiety Treatment (CANMAT), which has a strong influence on psychiatrists worldwide, published its fourth revision of the guidelines for the treatment of bipolar disorder in 2013 (CANMAT-IV), which recommends first-line treatment of manic episodes in the acute phase as lithium carbonate, valproate, second-generation antipsychotics alone or lithium carbonate or valproate in combination with second-generation antipsychotics such as risperidone, olanzapine, and quinine fumarate. olanzapine, quetiapine fumarate, aripiprazole treatment. Bipolar depression: The treatment of bipolar depression in the acute phase is still a big challenge, and only a few drugs have been proven to be effective. It is worth noting that in the current study, the only atypical antipsychotics proven to be effective for bipolar depression are quetiapine and the combination of oxyfluor (olanzapine and fluoxetine); clinically, patients with severe depression, suicidal ideation and behavior are usually treated with antidepressants on top of affect stabilizers. CANMAT-IV) does not recommend paroxetine because it is currently used in most negative outcome bipolar depression treatment studies. However, there is actually still a great deal of controversy regarding the use of antidepressants, with conflicting results from different studies and meta-analyses. A 2013 meta-analysis, which pooled 10 randomized controlled studies, showed that overall antidepressants are effective in the treatment of bipolar depression. However, antidepressants should not be used in patients with current mixed episodes or a history of rapid cycling.