Luo Jing, a famous CCTV announcer, passed away in Beijing after suffering from lymphoma. Over time, the number of patients with swollen lymph nodes or suspected lymphoma in our hematology clinic has increased dramatically. Most of the patients with swollen lymph nodes usually show limited lymph node enlargement, and no foci of infection can be found in the tissues of their draining areas. Some patients even suspect that they have lymphoma even though they do not have swollen lymph nodes on their body surface and only have mild symptoms such as fatigue or dizziness. In fact, there is no need to be so alarmed about the swollen lymph nodes in general. The following are the main causes of swollen lymph nodes: a. Infectious lymph node enlargement, accounting for the vast majority, including non-specific lymphadenitis, specific infectious lymph node enlargement (such as lymph node tuberculosis, filarial lymphadenitis and lymphadenitis, venereal lymph node enlargement, serotoxic lymphadenitis), systemic infections caused by swollen lymph nodes (such as infectious mononucleosis, rubella, measles, cat Scratch disease, scrub typhus, glandular plague, scarlet fever, leptospirosis, rat bite fever, toxoplasmosis, rabbit fever, black fever, etc.). Neoplastic enlargement, including leukemia, lymphoma, plasmacytoma, histiocytosis, and lymph node metastasis from other malignant tumors. (3) Allergic lymph node enlargement, including reactive lymphadenitis, adult Sail disease, allergic subsepsis, acute necroproliferative lymphadenopathy, systemic lupus erythematosus, etc. Fourth, other lymph node enlargement, including nodular disease, fatty deposition disease, etc. It is one of the long-established diagnostic methods in medicine to determine whether the area suffers from infection by the enlargement of lymph nodes or not. When lymph node enlargement is detected, medical history, symptoms (such as fever, weight loss, night sweats, skin redness, swelling and heat pain, etc.), physical examination (including the location, size, softness and correlation of lymph nodes with surrounding tissues, etc.), routine blood and biochemical tests and other special tests (such as microbiological tests, bone marrow and lymph node biopsy, etc.) are required to determine the cause of the disease and propose an appropriate treatment plan. Medical history is helpful for the diagnosis and differential diagnosis of lymph node enlargement, such as acute lymph node enlargement with fever, which is mostly caused by infectious diseases; limited lymph node enlargement, where no foci of infection are found in the tissues of the drainage area, which is usually caused by non-specific inflammation; and generalized lymph node enlargement, which is most likely caused by viral infection. However, if a patient with progressive enlargement of lymph nodes is accompanied by prolonged low-grade fever, night sweats and weight loss, the possibility of lymphoma should be suspected. Lymph node palpation is also important to identify the cause of lymph node enlargement. A comprehensive analysis can be made based on the location, size, number, shape, hardness, pressure pain, mobility and local skin manifestations of the enlarged lymph nodes. Acute inflammatory lymph node enlargement is soft, with pressure and pain, smooth surface and no adhesions when it is just enlarged, and usually does not cause huge lymph node enlargement, which can be treated with antibiotics and can mostly subside quickly. Non-specific inflammation caused by limited lymph node enlargement, generally enlarged lymph nodes are relatively small, or flat, soft, no pressure pain, smooth surface, can be long-term or even accompanied by lifelong. Lymph node enlargement caused by lymph node tuberculosis, mostly occurs around the cervical vessels, varying in size, sometimes in bunches, may adhere to each other, and if caseous necrosis occurs, fluctuations may be palpable, often ulcerating in the late stage, forming fistulas that do not heal easily and forming irregular scars after healing. Lymph node enlargement caused by lymphoma is often painless, hard rubber-like and lumpy, and can be fused, but lymph node enlargement caused by fast-growing lymphoma can also be painful. Lymph node enlargement caused by malignant tumor metastasis is often hard in texture and usually without pressure pain. Of course, the following clinical manifestations should be considered as the possibility of lymphoma and need to be seen in the hematology or oncology clinics in time: 1. Progressive lymph node enlargement of unknown origin, especially if it is consistent with the characteristics of lymphoma in terms of location, hardness and activity (common lymph node enlargement in the neck and axillae with tough texture); 2. “3.Lymph node enlargement and fever, though repeated, tend to be progressive in general; 4.Unexplained long-term low fever or periodic fever, especially when accompanied by itchy skin, excessive sweating, wasting and superficial lymph nodes The lymph nodes are swollen, especially the lymph nodes in the slide car are swollen bilaterally.