Ketoacidosis, need to be based on the patient’s medical history and clinical manifestations (such as nausea, vomiting), combined with the hospital laboratory test indicators (such as acidosis, ketone body elevation) to make a comprehensive judgment. The causes of ketoacidosis mainly include poor glycemic control in diabetic patients, alcoholism, starvation, drugs, etc. The most common is diabetic ketoacidosis, which is characterized by hyperglycemia, dehydration and metabolic acidosis, and usually leads to aggravation of symptoms of diabetic patients such as polydrinking, polyuria, etc., which may be accompanied by gastrointestinal symptoms such as nausea and vomiting, loss of appetite, and there will be the smell of rotten apples to be exhaled. Patients should promptly seek medical attention to improve the relevant examinations, such as blood glucose, blood gas analysis, blood and urine routine, etc. If found that the ketone body is elevated, blood pH is reduced and other results, combined with the history and clinical manifestations can be determined as the occurrence of ketoacidosis. Ketoacidosis should be the first time to the local hospital for treatment, not blind judgment, in order to avoid deterioration of the condition.