A, ankylosing spondylitis joint pathological changes 1, synovitis synovitis is the earliest pathological changes in ankylosing spondylitis involved joints, microscopically can be seen in the inflammatory synovial tissue hyperplasia hypertrophy, villi formation, small blood vessels around the plasma cells and lymphocytes infiltration. This inflamed synovial tissue can release inflammatory mediators, causing painful swelling of the joint; it can release a variety of enzymes, destroying joint cartilage and bone tissue and eventually causing joint destruction. The lesions mostly start in the sacroiliac joints and gradually invade upward to the lumbar, thoracic and cervical spine. The shoulder joint, temporomandibular joint, transverse rib joint, cribriform joint, sternoclavicular joint, sternoclavicular stalk joint, and pubic symphysis are also often involved. This is a characteristic pathology of ankylosing spondylitis, in which aseptic inflammation occurs at the attachment sites of ligaments, tendons and joint capsules, and the granulation tissue generated during the inflammatory process can destroy cancellous bone. In the late stages of ankylosing spondylitis, the osteophytes of the affected joints become more and more obvious, especially the calcification or ossification of the joint capsule and ligaments is very prominent, and eventually the affected joint space completely disappears, and bony ankylosis occurs, this bony ankylosis often occurs in the sacroiliac joint, spine and hip, less often in the knee and ankle, this change occurs in the spine that forms the bamboo-like changes on X-ray. The pathological basis of the ankylosis. The treatment of ankylosing spondylitis quadruple therapy: 1, their own treatment, including maintaining a straight back, exercise lumbar activities, etc., in order to prevent spinal deformity, swimming is a better way; 2, drug therapy, the purpose is to relieve pain and anti-inflammatory, slowing the progress of the disease; 3, hormones, etc.; 4, biological agents, such as Yicep, and some immunosuppressive drugs, and of course, there are some Chinese herbal medicine, such as Lei Gong Vine. Third, ultramicroscopy – arthritis local treatment minimally invasive technology ultramicroscopy treatment technology is based on Western medicine anatomy, surgical operation, in the treatment process does not destroy the overall structure, only microscopic tissue structure changes, is the milli-needle and open surgery can not replace the new technology. The technology equipment includes electronic imaging system, optical imaging system and many patented medical devices, which are clinically applicable to most of the joints, spine and other soft tissue diseases. It transforms from blind operation to visual operation, allowing more accurate treatment, and plays an important role in the diagnosis and treatment of ankylosing spondylitis, especially the peripheral arthritis caused by it. Ultramicroscopy is more minimally invasive, more visualized and less expensive than simple arthroscopy in the loosening and anti-inflammatory treatment of joints such as frozen shoulder, knee arthritis and hip arthritis, and will gradually replace arthroscopy and become the mainstream of minimally invasive treatment. Fourth, the characteristics of ultramicroscopic treatment system: 1. Minimally invasive operation All ultramicroscopic operating instruments and operating methods are based on tiny incisions. Unlike arthroscopic treatment, arthroscopic treatment usually requires the opening of three or more channels at the surgical site to facilitate the operation, and the treatment process is based on cutting or exploitation of damaged mucosa, cartilage and other tissues, which is relatively more traumatic and has a relatively longer recovery time; ultramicroscopy in the treatment of painful orthopedic characteristics, the incision is less than 0.5cm, and up to two channels are opened, and sometimes a channel can be used to complete the During the treatment process, the joint and diseased tissues are peeled and unblocked and the joint cavity is irrigated to release adhesions, eliminate inflammation and restore function. Intraoperative trauma is relatively small, and functional exercise can be performed the day after surgery. 2.Visual operation The ultramicroscopic treatment technology uses imaging equipment for visual operation, and the operation channel is used for complex and dangerous parts, which reduces the danger of the operation and improves the success rate of the operation. For example, in the lateral saphenous fossa release surgery of the spine, an incision of about 0.3-0.5 cm is made and an operating channel is placed under the observation of the monitor to reach the intervertebral space, avoiding direct puncture and making a complex and dangerous operation simple and safe. 3.Simplification of operation Because of the small incision and less damage, it is generally not necessary to do intraoperative blood expulsion and tourniquet treatment, avoiding artifacts in the operating area caused by ischemia. The operation channel can be compatible with a variety of instruments, and a number of operations such as inspection, irrigation, injection, placement and ablation can be done in one channel, simplifying the complex operation. 4.Precise targeting and efficacy For refractory ankylosing spondylitis, such as joint and tendon local stubborn swelling and pain, as well as stiffness, the use of ultramicroscopy for local unblocking, stripping, irrigation, drug placement and other treatment can often eliminate the symptoms within a short time, lift the stiffness of the joint, restore the function of each joint, and can avoid damage to normal tissue. The ultramicroscopic technique uses local anesthesia and has a short hospital stay.