I have recently rescued several cases of severe “sulphur-like reaction to alcohol withdrawal”, although the patients were successfully rescued, but the rescue process is still shocking and difficult to forget. Many patients usually drink a lot, a small amount of alcohol, but serious discomfort and even life-threatening conditions, all because of the “alcohol withdrawal sulfur-like reaction” know little, now the “alcohol withdrawal sulfur-like reaction” to you a brief description, I hope you understand after the warning. Disulfiram is a drug that can cause serious discomfort even if a small amount of alcohol is consumed, and the purpose of abstinence from alcohol is achieved. However, it is not just disulfiram that can cause these discomforts, many drugs have similar effects to disulfiram, and if you drink alcohol after using the drug, it can also cause facial flushing, dizziness, headache, blurred vision, sweating, and in severe cases, respiratory distress, decreased blood pressure, cardiac arrhythmia, heart failure, shock, and even death. Because the symptoms are similar to those of alcohol consumption after exposure to disulfiram, it is called “disulfiram-like reaction”. Common drugs that cause “disulfiram-like reactions” are: 1, cephalosporins, such as cefoperazone, ceftriaxone, etc.; 2, imidazoles: such as metronidazole, ornidazole, etc.; 3, other antibacterial agents: such as furazolidone, ketoconazole, compound sulfamethoxazole, isoniazid, etc.; 4, sulfonylurea hypoglycemic drugs: such as gliclazide, glipizide 5.Other drugs: warfarin, tolazurin, etc. Cephalosporin antibiotics and other drugs cause alcohol withdrawal sulfur-like reactions, which may be similar to the structure of the parent nucleus (7-ACA) with the side chain of methyl tetrazolium sulfide and alcohol withdrawal sulfur compounds, which inhibit the activity of acetaldehyde dehydrogenase in vivo, resulting in an increase in acetaldehyde in vivo and producing alcohol withdrawal sulfur-like reactions. It has been reported in the literature that in addition to liquor, wine and beer, certain foods such as cheese, beef, sausage, broad beans, pineapple, bananas, curd, animal liver, fermented foods, tea, coffee-based foods, chocolate, drowned products, pine eggs, fish, marine fish, freshwater fish and mussels are rich in complex amines, dopamine, 5-hydroxytryptamine, histamine, phenylalanine, tryptophan, tyrosine, 3,4-hydroxy These foods are metabolized in the same way as ethanol, and if cephalosporin antibiotics are taken at the same time, a sulfur-like reaction to alcohol withdrawal can occur. The following nursing measures should be taken for patients with disulfiram-like reactions and anaphylaxis: 1, bed rest, close observation of the patient’s consciousness, temperature, pulse, respiration, heart rate, heart rhythm, blood pressure, urine volume and other clinical changes, and make nursing records of the dynamics of the condition. 2.Keep the airway unobstructed and give oxygen inhalation 4-6L/min to improve tissue hypoxia. 3.Establish intravenous access, rehydration to maintain normal blood pressure, can give dexamethasone 5-10mg into glucose solution in the static drip or static push, and give vasoactive drugs according to the condition of treatment. 4, symptomatic treatment: such as nausea, vomiting can be given gastric complex 10mg intramuscular injection; such as drowsiness, unconsciousness can be given naloxone antagonistic treatment. 5.Bedside emergency equipment and drugs, such as defibrillators, aspirators, tracheotomy and intravenous incision kits, respiratory stimulants, diuretics and other resuscitation drugs.