Cirrhosis is a pathological process characterized by structural disorders of the liver caused by various pathogenic factors. For a long time, cirrhosis and its complications have threatened the life and health of the global population. The appearance of nodules in the Department of Infection, Shanghai Public Health Clinical Center, Liu Xinian, indicates that the degree of cirrhosis is more severe and may transform to liver cancer. Strictly speaking, the regenerative nodules that appear in post-hepatitis B cirrhosis should not be described as benign nodules; its medical term is called regenerative nodules, and the so-called benign nodules are probably talking about regenerative nodules that have not yet transformed into liver cancer. How to prevent cirrhosis, among the causes of cirrhosis, most patients with cirrhosis are chronic hepatitis, a few are due to alcoholism and chronic schistosomiasis, and individual cases are related to genetic and metabolic diseases. The occurrence of cirrhosis of the liver in addition to the above-mentioned etiology, aflatoxin contamination in food is also an important etiology, and drinking water contamination is also a possible cause. 1. Regular screening for high-risk groups – We need to identify which patients with chronic liver disease are at risk for the development of cirrhotic liver nodules Since early diagnosis of liver cancer is crucial for effective treatment and long-term survival, great emphasis is placed on early screening and early surveillance of liver cancer. In addition to methemoglobin, other markers that can be used as an aid in the diagnosis of HCC are various serum enzymes, including r-glutamyl transpeptidase (GGT) and its isoenzymes, alpha-L-amylase (AFU), abnormal prothrombin (DCP), Golgi protein 73 (GP73), ferritin (FT), etc., placental-type glutathione S-transferase (GST), and abnormal prothrombin (DCP), and acid ferritin (AIF), etc. Some patients with HCC may have abnormally high carcinoembryonic antigen (CEA) and glycoantigen CA19-9. 2, regulate the mood, resolve the bad mood in the heart, so that they always have a good mood, beneficial to liver health care hepatitis B patients should do to keep the mood of optimism, do not be too nervous about the disease, with hepatitis B will not necessarily develop into cirrhosis, emotional tension, anger, irritability can lead to endocrine, plant nerve dysfunction, thus accelerating the change of the disease. 3, patients with cirrhosis should know which foods should be eaten more. 4, under the guidance of doctors, liver fibrosis cirrhosis treatment mainly includes: 1, remove the cause and reduce the original disease; 2, reduce tissue damage and promote epithelial repair; 3, anti-inflammatory drugs, regulation of inflammatory cells and immune response; 4, block myofibroblast proliferation and vascular proliferation; 5, block myofibroblast contraction; 6, antagonize fibrogenic cytokines and signals; 7, promote myofibro fibroblast apoptosis; 8, regulating metalloproteinase activity and antagonizing matrix metalloproteinase inhibitor activity. What is the best targeted antifibrotic treatment plan for each liver disease patient? These comprehensive treatments will bring great hope for a new era in the treatment of chronic liver disease and for improving the prognosis of patients with liver disease.