Some people can quickly get out of the shadow of the same failed marriage, while others are devastated and fall into the abyss of depression, so what kind of people are vulnerable to depression? Who does depression “favor”? (1) People with family members suffering from schizophrenia, bipolar disorder and depression have a high incidence, for example, if one of the parents suffers from depression, the prevalence of depression in their children is 25%, and the rate of monozygotic twins with depression is 50%. Beijing Huilongguan Hospital psychiatric department Zhang Ximei (2) adverse social environment: unsatisfactory marriage, poor economic status, poor interpersonal relationships, divorce, separation, and people living alone. (3) Inadequate personality: people who are generally anxious, impulsive, sensitive, perfectionist, cautious, stubborn and stereotypical are prone to depression. (4) Adverse childhood experiences: such as lack of love from both parents during childhood, childhood abuse or other adverse experiences such as overly strict parents. (5) Somatic conditions: chronic central nervous system diseases or other chronic somatic diseases are the high prevalence of depression, such as: malignant tumor, hypothyroidism, diabetes, coronary heart disease, Parkinson’s disease, epilepsy, etc. Some surveys show that the prevalence of depressive disorder in cancer patients is 33% to 42%, 45% within a few days after myocardial infarction, and 47% within 2 weeks after stroke; (6) Co-morbid psychiatric Abuse and dependence of active substances, such as alcohol-dependent patients. (7) The prevalence of depression is twice as high in women as in men, especially during the special stages of pregnancy, miscarriage, postpartum, and menopause. (8) People who are under high stress and fierce competition, due to disappointment, frustration and loss of confidence, leading to psychological imbalance. (9) People in a stressful state, such as: victims of certain social events, natural or man-made disasters, etc.