The latest guidelines consider the following four major groups to have clear benefit from statin use ① Those with clinically confirmed ASCVD (atherosclerotic cardiovascular disease), including coronary heart disease, ischemic stroke, and atherosclerotic peripheral vascular disease; ② Those with primary LDL-C ≥190 mg/dl; ③ Those aged 40-75 years with diabetes and LDL-C of 70-189 mg/dl ( 1.8-4.8 mmol/L); ④ Patients aged 40 to 75 years without coronary heart disease and diabetes but with a 10-year risk of cardiovascular events ≥7.5% and LDL-C of 70-189 mg/dl.