According to statistics, less than 1% of people have never had a headache in their life, and its incidence is second only to the flu. However, there are not many people who can seek timely and correct medical treatment. The main reason is that the etiology is complex (more than 300 kinds of headache etiology) and it is easy to cover up the disease; secondly, many patients and even doctors have misconceptions about headache and confusion in diagnosis and treatment and education, so that many chronic headache patients are in wrong medication, repeated head CT and magnetic resonance examination, which leads to untreated headache, complication of depression or increased risk of cardiovascular and cerebrovascular disease attack. Case 1: The patient was a female, 48 years old, with recurrent left-sided headaches for 15 years. The patient started to have intermittent attacks of left-sided headache 15 years ago, often with neck stiffness after fatigue, insomnia, and about half a day later with distending or pulling pain in the left temple or forehead, sometimes with throbbing pain, and the headache could extend to the whole left side of the head with moderate pain or more, affecting work and rest. At the same time, nausea, vomiting, dizziness and tinnitus appear. If headache powder is not taken, the headache usually lasts for 2-3 days. There is no significant discomfort in the interval. In the past 3 years, headache attacks are frequent and almost daily, so I need to take headache powder every day (5-6 packs/day) and the effect is far less than before. He sleeps poorly on weekdays. For the past 10 years, I have been seeking medical attention. He has been treated in several hospitals. Auxiliary examinations: 4 cranial CTs, 3 cranial MRIs showed no abnormalities; 5 cerebral hemograms, 3 accelerated and 2 slowed down blood flow. This case had been diagnosed as: 1. vascular headache 2. neurogenic headache 3. vascular-neurogenic headache. Treatment: 1. long-term use of headache powder 2. intermittent use of Zhentian pill, Tianma pill, Fenbid, etc. 3. intermittent intravenous administration of Ginkgo biloba, bitter disc, and other drugs to activate blood circulation and remove blood stasis. He came to our hospital and performed cervical MRI: cervical 3-4 and cervical 5-6 discs were found to be herniated. Our diagnosis: 1. cervicogenic headache 2. drug overdose headache. Our treatment: 1. discontinuation of headache powder 2. cervical disc cryo-plasma plus ozone minimally invasive ablation. Results: 3 months follow-up after discharge, only one mild headache episode. The 2005 International Headache Society’s headache classification criteria (2nd edition) clearly states that headache is divided into primary and secondary, and primary headache is divided into four types, including migraine, tension-type headache, cluster headache and other trigeminal autonomic headache, and other primary headache. Diagnoses such as vascular headache and neurogenic headache were eliminated from the International Classification of Headache criteria (1st edition) as early as 1988, but they are still in clinical use to date and patients are given the wrong treatment to activate blood circulation and remove blood stasis. More patients abuse painkillers, making the headache chronic and worse. In addition, patients with primary headache have very low positive rates for cranial CT and MRI, but they are still being repeatedly examined in outpatient emergency departments. Most tension-type headaches are caused by muscle tension, and there are many people who mistakenly believe that they are caused by mental tension. Case 2: The patient was a male, 38 years old, with recurrent right-sided headache for 3 years and recurrence for 7 days. It appeared every year in September and October, and the headache occurred almost every day during the attack period, sometimes twice a day. The main manifestation was pain in the right orbit and frontotemporal region with bursting-like pain, which was severe, accompanied by right eye congestion, lacrimation, fidgeting, irritability, and often nausea. There is no vomiting, photophobia, fear of sound, etc. The duration of each pain was about 2 hours, with no abnormal intervals. There were no positive findings in external cranial CT and MRI several times, and the diagnosis had been: 1. migraine 2. trigeminal neuralgia 3. ophthalmogenic headache. He had been treated with blood activation and blood stasis treatment, but it was ineffective. Our hospital diagnosed: cluster headache. The following treatment was given: 1. Oxygen administration by mask during the attack period 2. Lidocaine nasal drip 2. Intermittent period: stellate ganglion block on the sick side once a day for 10 days. Results: No similar headache attacks occurred in September and October of the following year.