When doctors recommend gallbladder stones or polyps patients to remove the gallbladder, many patients are reluctant, some are afraid of a knife, and some are worried that the body will “collapse” if the gallbladder is cut. In fact, the gallbladder only plays the role of storing and concentrating bile, it does not produce and secrete bile. The organ that really produces and secretes bile is the liver. After the gallbladder is removed, the bile storage and concentration function is lost, but the bile can still mix with food in the small intestine and play a digestive role. Moreover, most of the gallbladder stone or polyp surgeries are now done with minimally invasive laparoscopic techniques, which are less invasive and have faster recovery. However, is it superfluous for patients to have such concerns? From the information collected so far, although gallbladder removal solves the patient’s pain but there are still some unfavorable factors that need to be weighed before deciding to remove the gallbladder, here is a brief introduction to the adverse effects of gallbladder removal on people. 1, indigestion, bloating, diarrhea: In addition to the functions of storage, concentration and contraction, the gallbladder also has complex chemical functions and immune functions. The bile secreted by hepatocytes enters the gallbladder for storage and concentration along the bile ducts inside and outside the liver. After eating, under the regulation of the vagus nerve and cholecystokinin, the gallbladder contracts and expels bile into the intestinal lumen to participate in digestion. If the gallbladder is removed, bile is continuously drained into the intestine. There is no “storage bile” in the body to help, thus affecting the digestion and absorption of food, especially the digestion and absorption of fat, the result is to induce steatorrhea and fat-soluble vitamin deficiency; causing indigestion, bloating, diarrhea, wasting, etc. 2, the incidence of common bile duct stones increases after cholecystectomy: after gallbladder removal, the fluid pressure in the bile duct causes the pressure in the common bile duct to increase, which causes compensatory dilation of the common bile duct, in addition, the gallbladder has the function of concentrating bile, and the concentrated bile has higher solubility for cholesterol, while after gallbladder removal, the bile acid salt is obviously reduced, the concentration of bile loses its place, and the concentration of bile acid in the hepatic bile duct decreases leading to The dissolution ability of cholesterol is reduced, which, over time, will easily cause the accumulation of cholesterol to form stones. 3. The incidence of colon cancer may increase after surgery: In recent years, many European scholars found that among the cases of colon cancer, many of them have a history of gallbladder removal. The change of quality and quantity of bile after gallbladder removal may be the main cause of colon cancer, and further research is needed to prove this. 4.Alkaline reflux gastritis: After cholecystectomy, the loss of bile reserve function causes bile to change from intermittent and feeding-related excretion to continuous discharge into the duodenum, and the persistence of unmixed bile with food in the duodenum increases the chance of reflux into the stomach, leading to bile reflux gastritis. 5, post-cholecystectomy syndrome: modern post-cholecystectomy syndrome refers only to the inflammation and dyskinesia of Oddi’s sphincter that occurs after having cholecystectomy. Studies have shown that post-cholecystectomy can lead to sphincter of Oddi’s dysfunction. And this syndrome is very difficult to treat clinically.