How to cure severe depression, one is to prevent self-injury and suicide, because patients with severe depression often have strong thoughts of death or suicide as well as suicidal behavior. The first is to be hospitalized for a period of time, with 24-hour supervision by doctors and nurses, to prevent self-injury and suicide. The second is to adhere to adequate doses and long enough antidepressant treatment, if necessary, you can also choose to combine antipsychotic drugs or mood stabilizers, which can accelerate the onset of antidepressants, and can also increase the efficacy of antidepressants, and may also help patients with hallucinations, delusions, and symptoms of excitement, agitation, medication is generally recommended to carry on for more than two years, do not easily reduce the dose The medication is generally recommended for more than two years and should not be easily reduced or discontinued. The third is that when the patient’s depressive symptoms are in remission or intermittent, psychotherapy can also be carried out. Patients can be allowed to participate in group psychotherapy, so that they can communicate with other patients and feel that they are not alone, but that there are people who help and care for them, which can increase the patient’s self-confidence in treatment, improve the patient’s self-esteem and promote recovery.