Severe neurasthenia is not depression, but neurasthenia is a neurological disorder of the brain caused by various hidden causes, and patients mainly have sleep dysfunction, which can occur in various situations such as waking up early and dreaming during sleep or difficulty in falling asleep, but patients do not have psychological symptoms. Patients with depression can have sleep dysfunction and psychological symptoms. Sleep dysfunction is mainly waking up early and dreaming more during sleep, physical symptoms can also appear dizziness and lightheadedness, psychological symptoms can appear self-blame, disinterest in anything, lack of confidence in life, often have the desire to live lightly, and in serious cases patients may have the view of suicide, usually pay attention to care. Patients with neurasthenia and depression treatment methods are different, neurasthenia is mainly regulating nerve treatment, commonly used are glutamate, tranquilizer, depression patients apply citalopram antidepressant treatment.