Ankylosing spondylitis, also known as Marie-strümpell disease, Von Bechterew disease, rheumatoid spondylitis, deforming spondylitis, and rheumatoid central type, is now referred to as AS. AS is characterized by inflammation and ossification of the spinal joints and ligaments of the lumbar, cervical, and thoracic segments, as well as the sacroiliac joints, with frequent involvement of the hip joint and inflammation of other peripheral joints. The disease is generally rheumatoid factor negative, so it is collectively a seronegative spine disease along with Reiter’s syndrome, psoriatic arthritis, and enteropathic arthritis. Ankylosing spondylitis is actually a very ancient disease, with evidence of ankylosing spondylitis found in bones from ancient Egyptians thousands of years ago. 2000 years ago, Hippocrates, a famous Greek physician, described a disease in which the affected person had pain in the sacral, spinal, and cervical regions.